Congratulations to Professor Chas Bountra, Professor of Translational Medicine at the Nuffield Department of Medicine, who has been appointed OBE for services to Translational Medical Research in the New Year's Honours List 2018. Congratulations also to
Dr Jake Dunning, Honorary Visiting Research Fellow in Tropical Medicine (ERGO) who has been appointed MBE for services to Clinical Research.
Professor Chas Bountra, Co-Director of the Oxford Martin Programme on Affordable Medicines and Chief Scientist at the Structural Genomics Consortium, explains why a new approach to drug discovery and development is needed to address the urgent need for new drugs. In a new study, ‘A New Pharmaceutical Commons: Transforming Drug Discovery’, with colleagues, Dr Wen Hwa Lee, and Dr Javier Lezaun, call for ‘open science’ approaches to drug discovery and offer ways forward that would transform how the medical challenges of this century could be addressed more efficiently.
A multi-disciplinary research team from the Universities of Oxford, MRC LMB, Liverpool, Cancer Research UK and pharma (Forma Therapeutics) has performed structural studies of USP7 inhibitor-enzyme interactions, demonstrating that ubiquitin-specific proteases (USPs) are tractable drug targets for cancer and also other diseases. Professor Benedikt Kessler and Dr Adan Pinto-Fernandez from Oxford’s Target Discovery Institute were part of this study.
The Royal Society has awarded Professor Sir Peter Ratcliffe, Director of the Target Discovery Institute at the University of Oxford and Clinical Research Director at the Francis Crick Institute, with the Buchanan Medal for his ground-breaking research on oxygen sensing and signalling pathways mediating cellular responses to low oxygen levels or 'hypoxia'.
p53 is one of the most damaged genes in cancer. Because p53 stays inside the cells, it is not straightforward to identify and kill the cells with damaged p53. Now we have developed an antibody that recognises a p53 fragment presented on cancer cell surface and we show that this antibody is a promising new drug for cancer immunotherapy.
World Cancer Day takes place on February 4 each year. NDM researchers are trying to understand the epidemiology and potential causes of cancer, its effect on patient lives and outcomes, as well as the basic science underpinning the unregulated cell growth that is the hallmark of the disease. To mark World Cancer Day 2017, NDM has asked some of our cancer scientists about their research.
The burden caused by Alzheimer’s disease and other dementias represents one of the biggest problems for our healthcare systems. The last medicine was approved in 2002 and today we only have symptomatic treatments. ARUK-ODDI brings together chemists, biologist, psychiatrists and neuroscientists, many of them with pharmaceutical background, aiming to accelerate the discovery of novel and effective treatments, as explained by Dr John Davis.
The NDM Graduate Prize winners for 2016 are Emma Davenport, Symon Kariuki, Sarah McCuaig, Manuel Rivas and Joshua Tan. The winners were awarded a £500 prize. This year’s winners have worked across many research areas including malaria vaccine work, behavioural studies and software development.
Medical and health teaching and research at Oxford University has been ranked as the world's best for the sixth year running in the Times Higher Education World University Rankings. The discipline-specific tables, released today, follow on from last week's announcement that Oxford has been ranked the top university in the world by the same publication – the first time a UK institution has been awarded the accolade.