Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
Coleman OD., Macdonald J., Thomson B., Ward JA., Stubbs CJ., McAllister TE., Clark S., Amin S., Cao Y., Abboud MI., Zhang Y., Sanganee H., Huber KVM., Claridge TDW., Kawamura A.
We report the development of a potent and selective de novo cyclic peptide ligand for epigenetic methyllysine reader domain. The cyclic peptide binds at the aromatic cage of PHD-finger and modulates the JmjC lysine demethylase activity of KDM7.