Darragh O'Brien

Darragh O’Brien is a senior researcher in Translational Proteomics at the Nuffield Department of Medicine, University of Oxford, where he utilises biological mass spectrometry (MS) approaches to characterise and decipher mechanisms of human disease. His interests lie in how protein intrinsic disorder and post-translational modifications such as phosphorylation and ubiquitination contribute to protein function and disease, with a focus on Alzheimer's Disease (AD), neurodegeneration, and dementia. Before joining Oxford, Dr O’Brien spent several years as a researcher at Institut Pasteur in Paris, where he used integrative structural biology workflows to study the protein conformational dynamics of macromolecular systems. Post-doctoral work at University College London and PhD studies in Neuroscience at the Institute of Psychiatry, King’s College London further advanced his expertise. During his PhD, which was supervised by Professor Sir Simon Lovestone, he developed quantitative proteomic and MS strategies for AD biomarker discovery and validation in plasma and cerebrospinal fluid. Dr O’Brien’s scientific journey began with an Honors Degree in Biochemistry in 2004 from University College Dublin, where his undergraduate thesis explored mechanisms of amyloid processing in AD, under the guidance of Professor Dominic Walsh. Between 2005 and 2011, Dr O'Brien was also employed as a researcher at Proteome Sciences Plc in London, developing proteomic strategies for drug target discovery in CNS-related disorders.

Darragh heads the newly established Structural & Mechanistic Proteomics laboratory within the Nuffield Department of Medicine, which uses Hydrogen-Deuterium eXchange Mass Spectrometry (HDX-MS) to characterise the structure and conformational dynamics of biological systems.

For collaboration enquiries, please contact  darragh.obrien@ndm.ox.ac.uk