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Cyclin F.pngVincenzo d'Angiolella's group in the Oncology Department discovered that cancer cells die much faster when lacking the ubiquitin ligase adaptor Cyclin F as they accumulate E2F1, whose unrestricted activity promotes catastrophic replication stress upon Chk1 mediated checkpoint inhibition. Daniel Ebner and Benedikt Kessler from the TDI participated in this study.

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