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Aberrant accumulation of E2F1 upon cyclin F loss promotes DNA damage upon Chk1 inhibition - a novel anti-cancer strategy

21 August 2019

Cyclin F.png Vincenzo d'Angiolella's group in the Oncology Department discovered that cancer cells die much faster when lacking the ubiquitin ligase adaptor Cyclin F as they accumulate E2F1, whose unrestricted activity promotes catastrophic replication stress upon Chk1 mediated checkpoint inhibition. Daniel Ebner and Benedikt Kessler from the TDI participated in this study.