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Professor Sir Peter Ratcliffe has won one of the most prestigious prizes in medicine. The Lasker Awards recognise contributions that have allowed major advances in the understanding, diagnosis, treatment, and prevention of human disease. Professor Ratcliffe is to receive the prizes for his work understanding the mechanisms by which cells sense and signal hypoxia (low oxygen levels), an important component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia.