Breakdown of the epithelial barrier underpins inflammatory bowel disease (IBD), and the authors show that WFDC2 preserves the integrity of tight junctions between epithelial cells and prevents invasion by commensal bacteria and mucosal inflammation. Simon Davis, Roman Fischer and Benedikt Kessler from the TDI participated in this study.
Research identifies how the gut loses protective barrier function in IBD
7 March 2019
A single-cell based study from Prof Alison Simmons Lab describes clonic epithelial cell diversity in health and inflammatory bowel disease (IBD).