Structure shows how enzyme suppresses developmental protein
3 March 2015
A variety of signalling molecules ensure that the process of development from an undifferentiated ball of cells to an adult of the right size and shape proceeds according to plan. Matthias Zebisch from STRUBI, working with STRUBI co-head Yvonne Jones and other colleagues in Oxford and Jean-Paul Vincent’s group at the National Institute of Medical Resarch in Mill Hill, has discovered a unique feedback mechanism that controls one of the most important of these molecules. The result could have implications for the treatment of diseases including cancer and Alzheimer’s disease.