Adan Pinto Fernandez

Dr. Adán Pinto Fernández
Organisational affiliation: Benedikt M Kessler group (Proteomics and Mass Spectrometry).

Research focus:

Currently studying the functions of the Ubiquitin-Proteasome System (UPS) in disease using advanced mass spectrometry, proteomics and chemical biology as main tools. Adan’s past research includes different drug discovery programs and a number of cancer cell biology and signalling studies.

Featured publications:

1. Adán Pinto Fernández and Benedikt M Kessler. “DUBbing cancer: Deubiquitylating enzymes involved in epigenetics, DNA damage and the cell cycle as therapeutic targets”. Frontiers in Genetics 2016. doi: 10.3389/fgene.2016.00133.

2. Corbet C, Adán Pinto Fernández, Martherus R, Santiago de Jesus S, Polet F and Feron O. “Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation”. Cell Metabolism 2016 (In press).

3. Adán Pinto Fernández, Mace Y, Drouet F, Bony E, Boidot R, Draoui N, Lobysheva I, Corbet C, Polet F, Martherus R, Deraedt Q, Rodriguez J, Lamy C, Schicke O, Delvaux D, Louis C, Kiss R, Von Kriegsheim A, Dessy C, Elias B, Quetin-Leclercq J, Riant O and Feron O. “A new ER-specific photosensitizer unravels 1O2-driven inhibition of mTOR and proteasomal deubiquitinases as a generic mechanism for cancer photodynamic therapy”. Oncogene 2015 Dec 21. doi: 10.1038/onc.2015.474. [Epub ahead of print].

4. Adán Pinto Fernández*, Herrero A, Colón P, Casar B, Jones M,  Agudo-Ibáñez L, Vidal R, Tenbaum S, Nuciforo P, Valdizán EM, Horvath Z, Orfi L, Pineda-Luzena A, Palmer H, Keri G, Pazos A, Bony E, Rivas G, Gozalbes R, Hurlstone A and Crespo P. “Small molecule inhibition of ERK dimerization prevents tumorigenesis by Ras-ERK pathway oncogenes”. Cancer Cell, Volume 28, Issue 2, 10 August 2015, Pages 170–182. Referred to by Aroon S. Karra, Clinton A. Taylor IV, Curtis A. Thorne, Melanie H. Cobb in “A Kinase Divided” Cancer Cell, Volume 28, Issue 2, 10 August 2015, Pages 145-147. (*co-first author). 

5. Adán Pinto Fernández*, Berta Casar and Piero Crespo (2008). “Essential Role of ERK Dimers in the Activation of Cytoplasmatic but Not Nuclear Substrates by ERK-Scaffold Complexes”. Molecular Cell, Volume 31, Issue 5, 5 September 2008, Pages 708–721. Selected by The Faculty of 1000; Editorial in Science Sig. 1, ec315 2008. (*co-first autor).