Immunopeptidomics

Immunopeptidomics

ANTIGEN DISCOVERY

 

Dr. Nicola Ternette, together with Annalisa Nicastri and Robert Parker, is running a workflow in the TDI MS laboratory to analyse the MHC immunopeptidome - MHC class I & II derived antigens. This methodology can be applied to discover bacterial, parasite and viral, but also tumour and autoimmone antigens.

 

 

 

Selected references:

Nielsen M, Connelley T, Ternette N. Improved Prediction of Bovine Leucocyte Antigens (BoLA) Presented Ligands by Use of Mass-Spectrometry-Determined Ligand and in Vitro Binding Data. J Proteome Res. 2018 Jan 5;17(1):559-567. READ MORE

Li D, Bentley C, Anderson A, Wiblin S, Cleary KL, Koustoulidou S, Hassanali T, Yates J, Greig J, Olde Nordkamp M et al. 2017. Development of a T Cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy. Cancer Res, pp. canres.3247.2016-canres.3247.2016. Read more

Ternette N, Yang H, Partridge T, Llano A, Cedeño S, Fischer R, Charles PD, Dudek NL et al. 2016. Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells. Eur J Immunol, 46 (1),  Read more

Ternette N, Block PD, Sánchez-Bernabéu Á, Borthwick N, Pappalardo E, Abdul-Jawad S, Ondondo B, Charles PD, Dorrell L, Kessler BM, Hanke T. 2015. Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells. J Virol, 89 (11),  Read more

Chen L, Fischer R, Peng Y, Reeves E, McHugh K, Ternette N, Hanke T, Dong T et al. 2014. Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. Arthritis Rheumatol, 66 (2), Read more