Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.

Ward JA., Pinto-Fernandez A., Cornelissen L., Bonham S., Díaz-Sáez L., Riant O., Huber KVM., Kessler BM., Feron O., Tate EW.

DOI

10.1021/acs.jmedchem.0c00144

Type

Journal article

Journal

Journal of Medicinal Chemistry

Publisher

American Chemical Society (ACS)

Publication Date

28/02/2020

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