Direct relationship between virus load and systemic immune activation in HIV-2 infection
Leligdowicz A., Feldmann J., Jaye A., Cotten M., Dong T., McMichael A., Whittle H., Rowland-Jones S.
Immune activation is a hallmark of disease progression in human immunodeficiency virus (HIV) type 1 (HIV1) and HIV type 2 (HIV-2) infection. However, the relationship between viremia and systemic immune activation is unclear. We assessed the relationship between HIV-2 plasma virus load and immune system activation in a cross-sectional study in a community cohort of HIV-1-positive, HIV-2-positive, and HIV-negative patients, in which many HIV-2-positive patients had nonprogressing infection. HLA-DR and CD38 expression on CD4+and CD8+T cells was measured, as were plasma β2-microglobulin levels. These markers were related to clinical (virus load and CD4+cell count) and immunological (HIV-2-specific interferon γ secretion) correlates of delayed disease progression. A consistent positive correlation was identified between the level of HIV-2 viremia and immune activation. We propose that increasing virus load may contribute to systemic immune activation in HIV-2 infection. © 2009 by the Infectious Diseases Society of America. All rights reserved.