Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential

Zhao S., Johnston AM., Yiu CHK., Moreira LM., Reilly S., Wehrens XHT.

Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention that may be able to prevent and/or improve the current treatment paradigms for age-related AF. This review contributes to a holistic understanding of the intricate relationship between aging and AF.

DOI

10.20517/jca.2024.12

Type

Journal article

Journal

The Journal of Cardiovascular Aging

Publisher

OAE Publishing Inc.

Publication Date

08/11/2024

Volume

4

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