HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression.
Rai MA., Zhang Y., Yindom L-M., Holmes J., Yu L-M., Hao C., Rostron T., Yan H., Zhang YL., Cai C., McMichael AJ., Dong T., Rowland-Jones SL., Blais M-E., Xu KY.
We looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed an increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time.