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Quick and clean: A method for Pd-catalyzed Suzuki-Miyaura cross-coupling to iododeoxyuridine (IdU) in DNA is described. Key to the reactivity is the choice of the ligand and the buffer. A covalent [Pd]-DNA intermediate was isolated and characterized. Photocrosslinking probes were generated to trap proteins that bind to epigenetic DNA modifications.

Original publication

DOI

10.1002/anie.201304038

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

27/09/2013

Volume

52

Pages

10553 - 10558

Keywords

DNA, cross-coupling, oligonucleotides, palladium, photoaffinity labeling, Catalysis, DNA, Idoxuridine, Molecular Probes, Oligonucleotides, Palladium, Photoaffinity Labels