Methods and algorithms for extracting high-content signatures from cells, tissues, and model organisms
Rittscher J., Padfield D., Santamaria A., Tu J., Can A., Bello M., Gao D., Sood A., Gerdes M., Ginty F.
While high-content screening is already playing an important role in drug discovery, a growing number of academic laboratories are applying these techniques to conduct a system-level analysis of biological processes. In this context more complex assays and model systems are being imaged at higher throughput. Examples include co-culture assays, tissues, and entire model systems, as for example zebrafish. This summary presents examples of methods and algorithms that have been developed at GE Global Research that facilitate the quantitative analysis of such complex specimens.1© 2011 IEEE.