8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Bavetsias V., Lanigan RM., Ruda GF., Atrash B., McLaughlin MG., Tumber A., Mok NY., Le Bihan Y-V., Dempster S., Boxall KJ., Jeganathan F., Hatch SB., Savitsky P., Velupillai S., Krojer T., England KS., Sejberg J., Thai C., Donovan A., Pal A., Scozzafava G., Bennett JM., Kawamura A., Johansson C., Szykowska A., Gileadi C., Burgess-Brown NA., von Delft F., Oppermann U., Walters Z., Shipley J., Raynaud FI., Westaway SM., Prinjha RK., Fedorov O., Burke R., Schofield CJ., Westwood IM., Bountra C., Müller S., van Montfort RLM., Brennan PE., Blagg J.

DOI

10.1021/acs.jmedchem.5b01635

Type

Journal article

Journal

Journal of Medicinal Chemistry

Publisher

American Chemical Society (ACS)

Publication Date

25/02/2016

Volume

59

Pages

1388 - 1409

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