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Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC.

Original publication

DOI

10.1007/s11596-016-1647-y

Type

Journal article

Journal

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

Publication Date

18/10/2016

Volume

36

Pages

700 - 704

Addresses

Department of Head and Neck Radiation Oncology, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830011, China.

Keywords

Humans, Nasopharyngeal Neoplasms, Neoplasm Metastasis, HLA-A Antigens, HLA-B Antigens, Neoplasm Staging, Prognosis, Disease-Free Survival, Retrospective Studies, Haplotypes, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Female, Male, Biomarkers, Tumor