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Publications

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.

Ratcliffe PJ., (2022), Clinical medicine (London, England), 22, 23 - 33

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.

Eckardt L. et al, (2021), Endocr Relat Cancer, 28, 757 - 772

Corrigendum: Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Clifford SC. et al, (2021), Human molecular genetics, 30, 844 - 845

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

Wing PAC. et al, (2021), Cell reports

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia

Jatho A. et al, (2021), Circulation Research

Endothelial Oxygen Sensing in Alveolar Maintenance.

Hodson E. and Ratcliffe PJ., (2020), American journal of respiratory and critical care medicine

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.

Lauer V. et al, (2020), The Journal of biological chemistry, 295, 4065 - 4078

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.

Lauer V. et al, (2020), The Journal of biological chemistry, 295, 4065 - 4078

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Schmid V. et al, (2019), Scientific Reports, 9

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Cockman ME. et al, (2019), eLife

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.

Masson N. et al, (2019), Science, 365, 65 - 69

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

Fielding JW. et al, (2018), The Journal of Physiology, 596, 4393 - 4412

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S. et al, (2018), Nature chemical biology

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.

Tiana M. et al, (2017), Nucleic acids research

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Sadiku P. et al, (2017), Journal of Clinical Investigation, 127, 3407 - 3420

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

Grampp S. et al, (2017), PLoS Genet, 13, e1006872 - e1006872

New horizons in hypoxia signaling pathways

Pugh CW. and Ratcliffe PJ., (2017), Experimental Cell Research, 356, 116 - 121

Signalling hypoxia by protein hydroxylation: Transcriptional architecture of the HIF response

Ratcliffe PJ., (2017), FASEB JOURNAL, 31

A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.

Paolini NA. et al, (2017), Am J Hum Genet, 100, 506 - 522

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