Research Overview

The Epigenetics and Cellular Biology group establishes cellular model systems to establish the efficacy of the developed inhibitors and then further uses them to increase the knowledge of the biological function of the targeted proteins as well as validate their role in disease as a target for pharmacological intervention. The generation of chemical probes is a major effort involving now eight pharmaceutical companies as well as a network of academic collaborators is also managed by my team. Apart from chemical probe development my group is also part of a European network “Affinomics” which aims to generate antibodies against 1000 targets involved in cancer.