Mass Spectrometry for Target Discovery in Human Disease
The discovery of molecular principles underlying human disease is the driving force of finding new cures. Mass spectrometry can help discovering critical ‘molecular windows’ within complex disease processes. In our group, we study protein function, dynamics, posttranslational modifications and their effects on protein turnover, antigen presentation and metabolic pathways. We have developed specific expertise in mass spectrometry to address the following areas:
- Protein ubiquitination and protease biology (Benedikt Kessler, Adan Pinto-Fernandez)
- Phosphoproteomics, (Roman Fischer, Raphael Heilig)
- Protein methylation, acetylation, glycosylation, oxidation, citrullination and other posttranslational modifications (Roman Fischer, Raphael Heilig, Iolanda Vendrell, Simon Davis)
- Translational mass spectrometry (clinical proteomics - Roman Fischer, Simon Davis, Raphael Heilig, Zhanru Yu)
- Metabolomics/lipidomics (Georgina Berridge, Hannah Claire Scott, Zhanru Yu)
Expanding analytical capabilities using integrative approaches will ultimately lead to a more comprehensive picture of molecular processes in human disease.