Adán Pinto-Fernández
PhD
Career Development Fellow at Chinese Academy of Medical Sciences Oxford Institute (CAMS) - Nuffield Department of Medicine
TRANSLATIONAL STUDIES OF THE UBIQUITIN SYSTEM - CANCER IMMUNOLOGY
Current research involves the study of the roles of a class of druggable enzymes called deubiquitylating enzymes (DUBs) in cancer inflammation using advanced proteomics, lipidomics, and immunology techniques as main tools.
For instance, we have recently discovered that cancer cells lacking the DUB USP18, a negative regulator of the interferon pathway, are more antigenic and radiosensitive. At a molecular level, USP18-deficient cells accumulate innate immune ligands such as dsRNA, enhance the antigen presentation machinery, and hence they can activate more efficiently cytotoxic T cells, resulting in enhanced T cell killing and immunotherapy responses.
Pinto-Fernandez, A., Salio, M., Partridge, T. et al. Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity. Br J Cancer 124, 817–830 (2021). https://doi.org/10.1038/s41416-020-01167-y
Recent publications
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Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
Journal article
Pinto-Fernández A. et al, (2019), Frontiers in Chemistry, 7
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Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting
Journal article
Olie CS. et al, (2019), iScience, 12, 318 - 332
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Human Platelet Protein Ubiquitylation and Changes following GPVI Activation
Journal article
Unsworth A. et al, (2019), Thrombosis and Haemostasis, 119, 104 - 116
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A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN
Journal article
Weber A. et al, (2017), Cell Chemical Biology, 24, 1299 - 1313.e7
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Journal article
Turnbull AP. et al, (2017), Nature, 550, 481 - 486