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Hannah Scott

Research Assistant

Research in lipidomics, ubiquitin biology and cancer immunology

I work at the Nuffield Department of Clinical Medicine (NDM) in the Mass Spectrometry and Life Sciences group (Kessler lab) within the Target Discovery Institute (TDI), the Centre for Medicines Discovery (CMD) and the Translational Ubiquitomics-Cancer Immunology group (Pinto-Fernandez lab) within the Chinese Academy of Medical Sciences Oxford Institute (CAMS-COI).

My research focusses on lipidomics, ubiquitin biology and cancer immunology. My research projects are based on:

1. Deubiquitylating enzymes (DUBs) of which ubiquitin specific protease 18 (USP18) and USP19 are of particular interest, especially their potential roles in lipid metabolism, inflammation, cancer immunology, muscle diseases, women's health, obesity and ageing.

2. Providing lipidomics and metabolomics analyses to collaborative partners as part of the Metabolomics Small Research Facility.

My publications

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A.
Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6.PMID: 38055744

Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia.

Scott HC, Draganov SD, Yu Z, Kessler BM, Pinto-Fernández A.
Int J Mol Sci. 2023 Oct 24;24(21):15513. doi: 10.3390/ijms242115513.

USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

E. Josue Ruiz, Adan Pinto-Fernandez, Andrew P. Turnbull, Linxiang Lan , Thomas M. Charlton, Hannah Claire Scott, Andreas Damianou, George Vere, Eva M. Riising, Clive Da Costa, Wojciech W. Krajewski, David Guerin, Jeffrey Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan C. O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J. Dinsmore, Tim R. Hammonds, Sunkyu Kim, David Komander, Sylvie Urbé, Michael J. Clague, Benedikt M. Kessler and Axel Behrens.

eLife 2021;10:e71596

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

P A, Salio M, Partridge T, Chen J, Vere G, Greenwood H, Olie CS, Damianou A, Scott HC, Pegg HJ, Chiarenza A, Díaz-Saez L, Smith P, Gonzalez-Lopez C, Patel B, Anderton E, Jones N, Hammonds TR, Huber K, Muschel R, Borrow P, Cerundolo V, Kessler BM.

Br J Cancer. 2020 Nov 20

Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ.

Life Sci Alliance. 2020 Jul 7;3(8)

Pinto-Fernández A, Davis S, Schofield AB, Scott HC, Zhang P, Salah E, Mathea S, Charles PD, Damianou A, Bond G, Fischer R, Kessler BM.

Front Chem. 2019 Aug 29;7:592

Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA.

J Invest Dermatol. 2014 Jul;134(7)

Protein Fractionation for Quantitative Plasma Proteomics by Semi-Selective Precipitation

Ekaterina Mostovenko, Hannah C. Scott, Oleg Klychnikov, Hans Dalebout, André M. Deelder and Magnus Palmblad

J Proteomics Bioinform 2012, 5:9