Contact information
NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ UK
Paul Brennan
PhD, FRSC
Professor of Medicinal Chemistry
- Director – Centre for Medicines Discovery
- Director of Chemistry – Chemical Probes Portal
My research group works at the interface of chemistry and biology to design probes and inhibitors to investigate the intricate workings of human proteins and cells, with particular interest in epigenetic proteins, small GTPases, and dementia. Research interests include medicinal chemistry, fragment- and structure-based drug design, computational chemistry, organic synthesis, and biochemistry. The group is part of the Alzheimer's Research UK Oxford Drug Discovery Institute (ODDI), and Centre for AI in Precision Medicine at the University of Oxford.
More Information
Recent publications
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Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.
Journal article
Mackinnon SR. et al, (2024), Biochimie
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Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Preprint
O’Brien DP. et al, (2024)
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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
Journal article
Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259
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Transfer learning for Heterocycle Synthesis Prediction
Preprint
Wieczorek E. et al, (2024)
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Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
Journal article
Xiong Y. et al, (2024), Journal of medicinal chemistry