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Rational discovery of therapeutic PAK1 allosteric activators

He Y., Bae JSH., Nowak E., Outeiral C., Nissley DA., Tumber A., Berridge G., Salah E., Wang Y., He W., Zhang H., Chen T., Tusk S., Mathea S., Wang Y-J., Grassam-Rowe A., Kukura P., Schofield CJ., O’Brien DP., Pierangelini A., Churchill GC., Lanyon-Hogg T., Ke Y., Xu C., Ye T., Watkins H., Ying L., Koschinski A., Solaro RJ., Tan X., Bolla JR., Wang X., Knapp S., Deane CM., Zaccolo M., Nowotny M., Lei M.