Rob completed his MChem degree in 2016 at the University of Edinburgh, where he spent a year in France working with Dr Nicolas Blanchard of the Université de Strasbourg on the development of intramolecular inverse electron-demand [4+2] cycloadditions for the synthesis of pharmacologically relevant pyridine derivatives. During his final year project, he worked with Professor Guy Lloyd-Jones on the application of a gold catalysed C-H arylation reaction as a means of modifying BINOL phosphoric acids.
Rob's research interests are in the field of chemical biology, particularly with regards to the chemistry of living systems, and how it can be used to investigate the pathology and treatment of disease. He joined the EPSRC Synthesis for Biology and Medicine CDT in 2016 and is currently undertaking a DPhil project researching the use of chemogenomics for the treatment of neurodegenerative diseases. Outside of the lab, Rob is a keen rugby player, and enjoys cooking and reading.
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985
Post-translational site-selective protein backbone α-deuteration
Galan SRG. et al, (2018), Nature Chemical Biology, 14, 955 - 963
Intramolecular Inverse Electron-Demand [4 + 2] Cycloadditions of Ynamides with Pyrimidines: Scope and Density Functional Theory Insights
Duret G. et al, (2017), The Journal of Organic Chemistry, 82, 1726 - 1742
Boron chemistry in a new light
Duret G. et al, (2015), Chemical Science, 6, 5366 - 5382