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What is Target Discovery?

Target discovery helps identifying drug targets, molecules or molecular interactions at a critical point in a disease-causing pathway that are predicted to being amenable to therapeutic manipulation. The centre aims to link recent advances in genetics, genomics, cell and chemical biology for improved drug target discovery. A more specific focus for refining and validating such targets will provide a better link between traditional "open ended" academic processes to biomedical research and the need of the pharmaceutical industry for accurately defined targets to accelerate drug development.

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Structure shows how enzyme suppresses developmental protein

Structure shows how enzyme suppresses developmental protein

Posted 03/03/2015

A variety of signalling molecules ensure that the process of development from an undifferentiated ball of cells to an adult of the right size and shape proceeds according to plan. Matthias Zebisch from STRUBI, working with STRUBI co-head Yvonne Jones and other colleagues in Oxford and Jean-Paul Vincent’s group at the National Institute of Medical Resarch in Mill Hill, has discovered a unique feedback mechanism that controls one of the most important of these molecules. The result could have implications for the treatment of diseases including cancer and Alzheimer’s disease.

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