Target discovery helps identifying drug targets, molecules or molecular interactions at a critical point in a disease-causing pathway that are predicted to being amenable to therapeutic manipulation. The centre aims to link recent advances in genetics, genomics, cell and chemical biology for improved drug target discovery. A more specific focus for refining and validating such targets will provide a better link between traditional "open ended" academic processes to biomedical research and the need of the pharmaceutical industry for accurately defined targets to accelerate drug development.
Recent reports suggest that artemisinin drug resistance is emerging and spreading in many parts of the Asian Mekong region.
A study published today by NDM researchers in Lancet Infectious Diseases reports that the spread of artemisinin drug resistance is following the same historical route as resistance to other antimalarial drugs, chloroquine and sulfadoxine/pyrimethamine.