Target discovery helps identifying drug targets, molecules or molecular interactions at a critical point in a disease-causing pathway that are predicted to being amenable to therapeutic manipulation. The centre aims to link recent advances in genetics, genomics, cell and chemical biology for improved drug target discovery. A more specific focus for refining and validating such targets will provide a better link between traditional "open ended" academic processes to biomedical research and the need of the pharmaceutical industry for accurately defined targets to accelerate drug development.
NDM researchers have discovered a novel DNA recycling mechanism that normally protects cells, but which could potentially be turned against certain cancer cells.
In a study published in Nature, the lead author Dr Skirmantas Kriaucionis described how their study uncovered 'loopholes' in the recycling of modified DNA bases that can be exploited for cancer intervention.