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Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model
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Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells
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Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
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The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
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Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells
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GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.
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Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells
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Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation
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A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases.
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COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK
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Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection.
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Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK
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DEcancer: Machine learning framework tailored to liquid biopsy based cancer detection and biomarker signature selection
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Disparities in care and outcomes for primary liver cancer in England during 2008-2018: a cohort study of 8.52 million primary care population using the QResearch database.
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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination.
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Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
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Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
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Open resources for chemical probes and their implications for future drug discovery
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