Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
Lienard BM., Conejo-García A., Stolze I., Loenarz C., Oldham NJ., Ratcliffe PJ., Schofield CJ.
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.