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Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

Original publication

DOI

10.1002/ejoc.201901187

Type

Journal article

Journal

European Journal of Organic Chemistry

Publication Date

22/09/2019

Volume

2019

Pages

6132 - 6137