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The PD-1/PD-L1 interaction has emerged as a significant target in cancer immunotherapy. Current medications include monoclonal antibodies, which have shown impressive clinical results in the treatment of several types of tumors. The cocrystal structure of human PD-1 and PD-L1 is expected to be a valuable starting point for the design of novel inhibitors, along with the recent crystal structures with monoclonal antibodies, small molecules, and macrocycles.

Original publication

DOI

10.1002/anie.201710407

Type

Journal article

Journal

Angewandte Chemie (International ed. in English)

Publication Date

04/2018

Volume

57

Pages

4840 - 4848

Addresses

Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.

Keywords

Humans, Neoplasms, Antibodies, Monoclonal, Ligands, Immunotherapy, Drug Design, Molecular Targeted Therapy, Programmed Cell Death 1 Receptor, Antineoplastic Agents, Immunological, B7-H1 Antigen