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Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

Original publication

DOI

10.1084/jem.20050390

Type

Journal article

Journal

J Exp Med

Publication Date

23/01/2006

Volume

203

Pages

141 - 152

Keywords

Animals, Autoantigens, Autoimmunity, Capillary Permeability, Hindlimb, Homeodomain Proteins, Immunity, Innate, Immunoglobulin M, Ischemia, Jejunum, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Skeletal, Nonmuscle Myosin Type IIA, Reperfusion Injury