Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials.
Smith TG., Talbot NP., Privat C., Rivera-Ch M., Nickol AH., Ratcliffe PJ., Dorrington KL., León-Velarde F., Robbins PA.
Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial pressure may depend on iron status, possibly acting through the transcription factor hypoxia-inducible factor, but the pathophysiological and clinical importance of this interaction is unknown.