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Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial pressure may depend on iron status, possibly acting through the transcription factor hypoxia-inducible factor, but the pathophysiological and clinical importance of this interaction is unknown.

Original publication

DOI

10.1001/jama.2009.1404

Type

Journal article

Journal

JAMA

Publication Date

07/10/2009

Volume

302

Pages

1444 - 1450

Addresses

Department of Physiology, Anatomy, and Genetics, University of Oxford, Sherrington Bldg, Parks Road, Oxford OX1 3PT, England.

Keywords

Adult, Altitude, Altitude Sickness, Anoxia, Blood Pressure, Cross-Over Studies, Double-Blind Method, Echocardiography, Doppler, Ferric Compounds, Humans, Hypertension, Pulmonary, Iron, Male, Middle Aged, Phlebotomy, Pulmonary Artery, Systole, Young Adult