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Publications

Tau depletion in human neurons mitigates Aβ-driven toxicity.

Ng B. et al, (2024), Molecular psychiatry

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

Gan J. et al, (2023), Proceedings of the National Academy of Sciences, 120

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

O'Brien DP. et al, (2023), Molecular & Cellular Proteomics, 22, 100609 - 100609

Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection

Bharucha T. et al, (2023), Journal of Proteome Research, 22, 1614 - 1629

Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

O’Brien DP. et al, (2022), Clinical Proteomics, 19

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Kotanidis CP. et al, (2022), The Lancet Digital Health, 4, e705 - e716

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58

Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19

Vere G. et al, (2022), Biomolecules, 12, 300 - 300

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

Voegele A. et al, (2021), Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8

Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics

Thorne AM. et al, (2020), Clinical Proteomics, 17

Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.

O'Brien DP. et al, (2020), Methods in molecular biology (Clifton, N.J.), 2127, 339 - 358

Post-translational acylation controls the folding and functions of the CyaA RTX toxin.

O'Brien DP. et al, (2019), FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33, 10065 - 10076

Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) ofBordetella pertussis

Voegele A. et al, (2018), Pathogens and Disease, 76

SEC-SAXS and HDX-MS: A powerful combination. The case of the calcium-binding domain of a bacterial toxin.

O'Brien DP. et al, (2018), Biotechnology and applied biochemistry, 65, 62 - 68

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

O'Brien DP. et al, (2017), PLoS biology, 15

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins.

Hamdi K. et al, (2017), Scientific reports, 7

MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.

Hourdel V. et al, (2016), Bioinformatics (Oxford, England), 32, 3413 - 3419

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.

Jenkinson C. et al, (2016), Clinical cancer research : an official journal of the American Association for Cancer Research, 22, 1734 - 1743

Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.

Lawrenson K. et al, (2015), International journal of cancer, 137, 1806 - 1817

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.

O'Brien DP. et al, (2015), Scientific reports, 5

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