Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
O’Brien DP. et al, (2025), Journal of Proteome Research, 24, 479 - 490
Deubiquitinases in muscle physiology and disorders
Olie CS. et al, (2024), Biochemical Society Transactions, 52, 1085 - 1098
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1
Imhoff RD. et al, (2024), Journal of Medicinal Chemistry, 67, 4496 - 4524
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
O'Brien DP. et al, (2023), Molecular & Cellular Proteomics, 22, 100609 - 100609
ABPP-HT*—Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods
Jones HBL. et al, (2022), International Journal of Molecular Sciences, 23, 3263 - 3263
Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover
Winter SD. et al, (2021), ACS Catalysis, 11, 14854 - 14863
Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes
Subramanian S. et al, (2021), ACS Applied Nano Materials, 4, 4576 - 4583
ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context
Jones HBL. et al, (2021), Frontiers in Chemistry, 9
Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift
Knight MJ. et al, (2020), Biochemical Journal, 477, 3599 - 3612