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Publications

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

O'Brien DP. et al, (2023), Molecular & Cellular Proteomics, 22, 100609 - 100609

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

Rusilowicz-Jones EV. et al, (2020), Life Science Alliance, 3, e202000768 - e202000768

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Le Bihan Y-V. et al, (2019), European Journal of Medicinal Chemistry, 177, 316 - 337

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Tumber A. et al, (2017), Cell Chemical Biology, 24, 371 - 380

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Jones P. et al, (2017), Journal of Medicinal Chemistry, 60, 767 - 786

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Bavetsias V. et al, (2016), Journal of Medicinal Chemistry, 59, 1388 - 1409

Recent Progress in Histone Demethylase Inhibitors

McAllister TE. et al, (2016), Journal of Medicinal Chemistry, 59, 1308 - 1329

Targeting histone lysine demethylases — Progress, challenges, and the future

Thinnes CC. et al, (2014), Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839, 1416 - 1432

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

England KS. et al, (2014), MedChemComm, 5, 1879 - 1886

Acidic triazoles as soluble guanylate cyclase stimulators

Roberts LR. et al, (2011), Bioorganic & Medicinal Chemistry Letters, 21, 6515 - 6518

An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole

England K. et al, (2010), Tetrahedron Letters, 51, 2849 - 2851

Include forthcoming?