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Publications

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

Fejes I. et al, (2024), Journal of medicinal chemistry

Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300

Chen X. et al, (2024), JACS Au

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.

Digles D. et al, (2024), Frontiers in pharmacology, 15

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Raux B. et al, (2024), Bioorganic & medicinal chemistry letters, 98

Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.

Ji H. et al, (2023), Cell chemical biology

Open resources for chemical probes and their implications for future drug discovery

Balıkçı E. et al, (2023), Expert Opinion on Drug Discovery, 18, 505 - 513

Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.

Martinelli P. et al, (2023), ChemMedChem

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Coleman OD. et al, (2023), Chemical Science

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT. et al, (2023), Journal of medicinal chemistry, 66, 460 - 472

Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.

Rothweiler EM. and Huber KVM., (2023), Methods in molecular biology (Clifton, N.J.), 2706, 191 - 200

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.

Ketley RF. et al, (2022), Cell reports, 41

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

Mackinnon SR. et al, (2021), ACS Chemical Biology

TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Feyertag F. and Huber KVM., (2021)

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Pinto-Fernandez A. et al, (2021), British Journal of Cancer, 124, 817 - 830

Assays to Characterize the Cellular Pharmacology of a Chemical Probe

Stefaniak J. et al, (2021), DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY, 16, 247 - 275

Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Álvarez-Coiradas E. et al, (2020), International immunopharmacology, 89

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion

Kidd SL. et al, (2020), Chemical Science, 11, 10792 - 10801

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