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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Journal article

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

Journal article

Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123

Assays to Characterize the Cellular Pharmacology of a Chemical Probe



Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Journal article

Álvarez-Coiradas E. et al, (2020), International immunopharmacology, 89

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

Journal article

Pinto-Fernandez A. et al, (2020), British journal of cancer

Quantifying CDK inhibitor selectivity in live cells.

Journal article

Wells CI. et al, (2020), Nature communications, 11

Quantifying Target Occupancy of Small Molecules Within Living Cells.

Journal article

Robers MB. et al, (2020), Annual review of biochemistry

Importance of Quantifying Drug-Target Engagement in Cells

Journal article

Stefaniak J. and Huber KVM., (2020), ACS Medicinal Chemistry Letters

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

Journal article

Fagan V. et al, (2019), Journal of Medicinal Chemistry

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Journal article

Böttcher J. et al, (2019), Nat Chem Biol, 15, 822 - 829

Regulation of influenza A virus mRNA splicing by CLK1.

Journal article

Artarini A. et al, (2019), Antiviral Res, 168, 187 - 196

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Journal article

Resnick E. et al, (2019), Journal of the American Chemical Society, 141, 8951 - 8968

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Journal article

Vazquez-Rodriguez S. et al, (2019), Angewandte Chemie International Edition, 58, 515 - 519

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