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TargetDB: A target information aggregation tool and tractability predictor

Journal article

De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

Inhibitors of JmjC-Containing Histone Demethylases


Wright M. et al, (2020), Topics in Medicinal Chemistry, 33, 221 - 253

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

Journal article

Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666

A chemical toolbox for the study of bromodomains and epigenetic signaling

Journal article

Wu Q. et al, (2019), Nature Communications, 10

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

Journal article

Fagan V. et al, (2019), Journal of Medicinal Chemistry

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

Journal article

Xiong Y. et al, (2019), Journal of Medicinal Chemistry

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Journal article

Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Journal article

Resnick E. et al, (2019), Journal of the American Chemical Society, 141, 8951 - 8968

Targeting the Small GTPase Superfamily through their Regulatory Proteins

Journal article

Gray JL. et al, (2019), Angewandte Chemie International Edition

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Journal article

D'Ascenzio M. et al, (2019), Angewandte Chemie International Edition, 58, 1007 - 1012

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Journal article

Vazquez-Rodriguez S. et al, (2019), Angewandte Chemie International Edition, 58, 515 - 519

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Journal article

Hassell-Hart S. et al, (2019), Organometallics

Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)

Journal article

Heidenreich D. et al, (2018), Journal of Medicinal Chemistry, 61, 10929 - 10934

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

Journal article

Moustakim M. et al, (2018), Angewandte Chemie International Edition, 57, 16302 - 16307

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