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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Journal article

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia

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Mould AW. et al, (2022), CNS Drugs, 36, 1 - 16

Target 2035-update on the quest for a probe for every protein

Journal article

Mueller S. et al, (2021), RSC MEDICINAL CHEMISTRY

The structural basis of fatty acid elongation by the ELOVL elongases

Journal article

Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

RHO to the DOCK for GDP disembarking: structural insights into the DOCK GTPase nucleotide exchange factors.

Journal article

Thompson AP. et al, (2021), The Journal of biological chemistry

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Journal article

Quinlan RBA. and Brennan PE., (2021), RSC Chemical Biology

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Journal article

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985

The Discovery and Utility of Chemical Probes in Target Discovery

Book

Brennan P. and Vazquez-Rodriguez S., (2020)

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death

Journal article

Cottone L. et al, (2020), Cancer Research, 80, 4540 - 4551

TargetDB: A target information aggregation tool and tractability predictor

Journal article

De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

Chemical Strategies for Evaluating New Drug Targets

Chapter

Carter AJ. et al, (2020), TARGET DISCOVERY AND VALIDATION: METHODS AND STRATEGIES FOR DRUG DISCOVERY, 1 - 24

Inhibitors of JmjC-Containing Histone Demethylases

Chapter

Wright M. et al, (2020), Topics in Medicinal Chemistry, 33, 221 - 253

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