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Publications

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents.

Fowkes MM. et al, (2022), PloS one, 17

Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia

Mould AW. et al, (2022), CNS Drugs, 36, 1 - 16

Target 2035-update on the quest for a probe for every protein

Mueller S. et al, (2021), RSC MEDICINAL CHEMISTRY

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Nizami S. et al, (2021), Scientific Reports, 11

Author Correction: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Nizami S. et al, (2021), Scientific Reports, 11

The structural basis of fatty acid elongation by the ELOVL elongases

Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

Mackinnon SR. et al, (2021), ACS Chemical Biology

RHO to the DOCK for GDP disembarking: structural insights into the DOCK GTPase nucleotide exchange factors.

Thompson AP. et al, (2021), The Journal of biological chemistry

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.

Doss PMIA. et al, (2021), Cell reports, 34

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Quinlan RBA. and Brennan PE., (2021), RSC Chemical Biology

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Sieberts SK. et al, (2020), Scientific Data, 7

The Discovery and Utility of Chemical Probes in Target Discovery

Brennan P. and Vazquez-Rodriguez S., (2020)

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death

Cottone L. et al, (2020), Cancer Research, 80, 4540 - 4551

TargetDB: A target information aggregation tool and tractability predictor

De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

Deliberately Losing Control of C-H Activation Processes in the Design of Small Molecule Fragment Arrays Targeting Peroxisomal Metabolism.

Kahn Tareque R. et al, (2020), ChemMedChem

TargetDB: A target information aggregation tool and tractability predictor

De Cesco S. et al, (2020)

Chemical Strategies for Evaluating New Drug Targets

Carter AJ. et al, (2020), TARGET DISCOVERY AND VALIDATION: METHODS AND STRATEGIES FOR DRUG DISCOVERY, 1 - 24

Inhibitors of JmjC-Containing Histone Demethylases

Wright M. et al, (2020), Topics in Medicinal Chemistry, 33, 221 - 253

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