A patent review of peptidylarginine deiminase 4 (PAD4) inhibitors (2014–present)
Aiken SG. et al, (2025), Expert Opinion on Therapeutic Patents, 1 - 11
Drug repurposing in amyotrophic lateral sclerosis (ALS)
Carroll E. et al, (2025), Expert Opinion on Drug Discovery, 1 - 18
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
O’Brien DP. et al, (2025), Journal of Proteome Research, 24, 479 - 490
Identification and characterization of human KALRN mRNA and Kalirin protein isoforms.
Mould AW. et al, (2024), Cerebral cortex (New York, N.Y. : 1991), 34
The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Sanfelice D. et al, (2024), Nucleic Acids Research
Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer.
Kapanidou M. et al, (2024), Biomolecules, 14
Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex
Giroud C. et al, (2024), Journal of Medicinal Chemistry
Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.
Mackinnon SR. et al, (2024), Biochimie
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
Xiong Y. et al, (2024), Journal of medicinal chemistry
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2
Bradshaw WJ. et al, (2024), Structure
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Bashore FM. et al, (2024), PloS one, 19
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Du Y. et al, (2023), The Journal of biological chemistry
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
O'Brien DP. et al, (2023), Molecular & Cellular Proteomics, 22, 100609 - 100609
The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
Fazazi MR. et al, (2023), Brain research bulletin
Open drug discovery in Alzheimer's disease.
Axtman AD. et al, (2023), Alzheimer's & dementia (New York, N. Y.), 9