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Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

Journal article

Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666

A chemical toolbox for the study of bromodomains and epigenetic signaling

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Wu Q. et al, (2019), Nature Communications, 10

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

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Fagan V. et al, (2019), Journal of Medicinal Chemistry

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

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Xiong Y. et al, (2019), Journal of Medicinal Chemistry

A genetics-led approach defines the drug target landscape of 30 immune-related traits

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Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

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Resnick E. et al, (2019), Journal of the American Chemical Society, 141, 8951 - 8968

Targeting the Small GTPase Superfamily through their Regulatory Proteins

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Gray JL. et al, (2019), Angewandte Chemie International Edition

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

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D'Ascenzio M. et al, (2019), Angewandte Chemie International Edition, 58, 1007 - 1012

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

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Vazquez-Rodriguez S. et al, (2019), Angewandte Chemie International Edition, 58, 515 - 519

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

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Hassell-Hart S. et al, (2019), Organometallics

Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)

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Heidenreich D. et al, (2018), Journal of Medicinal Chemistry, 61, 10929 - 10934

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

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Moustakim M. et al, (2018), Angewandte Chemie International Edition, 57, 16302 - 16307

Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides

Journal article

Wright M. et al, (2018), The Journal of Organic Chemistry, 83, 9510 - 9516

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2

Journal article

Moustakim M. et al, (2018), Bioorganic & Medicinal Chemistry, 26, 2965 - 2972

Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times

Journal article

Heroven C. et al, (2018), Angewandte Chemie International Edition, 57, 7220 - 7224

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces

Journal article

Bowkett D. et al, (2018), ChemMedChem, 13, 1051 - 1057

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