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Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

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Gerken PA. et al, (2017), Angewandte Chemie International Edition, 56, 15555 - 15559

Parallel reverse genetic screening in mutant human cells using transcriptomics

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Nijman S. et al, (2016), Molecular Systems Biology

A generic strategy for CRISPR-Cas9-mediated gene tagging.

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Lackner DH. et al, (2015), Nature communications, 6, 10237 - 10237

Functional genomics to uncover drug mechanism of action.

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Nijman SMB., (2015), Nature chemical biology, 11, 942 - 948

Light-assisted small-molecule screening against protein kinases.

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Inglés-Prieto Á. et al, (2015), Nature chemical biology, 11, 952 - 954

A thesaurus of genetic variation for interrogation of repetitive genomic regions.

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Kerzendorfer C. et al, (2015), Nucleic acids research, 43, e68 - e68

Targeting a cell state common to triple-negative breast cancers.

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Muellner MK. et al, (2015), Molecular systems biology, 11, 789 - 789

Synthetic lethal vulnerabilities of cancer.

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Fece de la Cruz F. et al, (2015), Annu Rev Pharmacol Toxicol, 55, 513 - 531

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

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Essletzbichler P. et al, (2014), Genome research, 24, 2059 - 2065

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.

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Licciardello MP. et al, (2014), Oncogene, 34, 3780 - 3790

Exploiting epigenetic vulnerabilities for cancer therapeutics.

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Mair B. et al, (2014), Trends Pharmacol Sci, 35, 136 - 145

Cancer. Potential of the synthetic lethality principle.

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Nijman SMB. and Friend SH., (2013), Science, 342, 809 - 811

A reversible gene trap collection empowers haploid genetics in human cells.

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Bürckstümmer T. et al, (2013), Nat Methods, 10, 965 - 971

Functional drug-gene interactions in lung cancer.

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Smida M. and Nijman SMB., (2012), Expert Rev Mol Diagn, 12, 291 - 302

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

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Muellner MK. et al, (2011), Nat Chem Biol, 7, 787 - 793

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