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McKeating Group
Established in 2017, the McKeating group in Oxford has been developing new methods to study the biology of hepatic liver disease. Recent advances include methods to identify the complex pattern of overlapping transcripts that are produced by viruses and new imaging approaches to visualise the genomes of HBV, HDV and other viruses within single cells. We are interested in the cellular basis of early infection events that define viral tropism and how this knowledge impacts pathogenesis and translates into new anti-viral strategies. We want to understand the simple, fundamental question of how, when and where do viruses replicate?
Medicinal Chemistry
The Medicinal Chemistry group designs and synthesises chemical probes to interrogate the function of target proteins in cellular systems. The group is currently focused on discovering chemical probes for epigenetic proteins.
TDI Mass Spectrometry Laboratory
Mass Spectrometry is key technology for studying critical molecules and pathways. Defining molecular targets is crucial for the process of drug development.
Chemical Biology
Our group uses chemical biology to uncover new principles of cellular regulation and identify points of intervention for future medicines. By designing small molecules that probe biological systems, we can reveal hidden mechanisms - and ultimately, develop strategies to restore cellular balance in disease.
Cellular High Throughput Screening (HTS)
The HTS facility provides Oxford research scientists and collaborators access to comprehensive, cost-effective, high throughput cell-based small compound and CRISPR screens across a broad range of readouts.