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Hannah Scott

Research Assistant

Research in metabolomics, lipidomics and ubiquitin biology

I work in at the Nuffield Department of Clinical Medicine (Research Building), in the Target Discovery Institute within the Medical and Life Science Division at the Mass Spectrometry and Life Sciences group (Kessler lab).

My research focusses on metabolomics, lipidomics and ubiquitin biology. My research projects are based on 1. deubiquitylating enzymes (DUBs) and cancer of which ubiquitin specific protease 18 (USP18) is of particular interest, especially its potential role in lipid metabolism, inflammation and immunity. 2. women’s health such as polycystic ovarian syndrome and uterine fibroids, targeting the role of USP19 and probing the function of steroid sex hormones and other lipids in these diseases and 3.) providing lipidomics and metabolomics analysis to collaborative partners as part of the Metabolomics Small Research Facility.

My publications

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A.
Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6.PMID: 38055744

Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia.

Scott HC, Draganov SD, Yu Z, Kessler BM, Pinto-Fernández A.
Int J Mol Sci. 2023 Oct 24;24(21):15513. doi: 10.3390/ijms242115513.

USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

E. Josue Ruiz, Adan Pinto-Fernandez, Andrew P. Turnbull, Linxiang Lan , Thomas M. Charlton, Hannah Claire Scott, Andreas Damianou, George Vere, Eva M. Riising, Clive Da Costa, Wojciech W. Krajewski, David Guerin, Jeffrey Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan C. O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J. Dinsmore, Tim R. Hammonds, Sunkyu Kim, David Komander, Sylvie Urbé, Michael J. Clague, Benedikt M. Kessler and Axel Behrens.

eLife 2021;10:e71596

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

P A, Salio M, Partridge T, Chen J, Vere G, Greenwood H, Olie CS, Damianou A, Scott HC, Pegg HJ, Chiarenza A, Díaz-Saez L, Smith P, Gonzalez-Lopez C, Patel B, Anderton E, Jones N, Hammonds TR, Huber K, Muschel R, Borrow P, Cerundolo V, Kessler BM.

Br J Cancer. 2020 Nov 20

Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ.

Life Sci Alliance. 2020 Jul 7;3(8)

Pinto-Fernández A, Davis S, Schofield AB, Scott HC, Zhang P, Salah E, Mathea S, Charles PD, Damianou A, Bond G, Fischer R, Kessler BM.

Front Chem. 2019 Aug 29;7:592

Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA.

J Invest Dermatol. 2014 Jul;134(7)

Protein Fractionation for Quantitative Plasma Proteomics by Semi-Selective Precipitation

Ekaterina Mostovenko, Hannah C. Scott, Oleg Klychnikov, Hans Dalebout, André M. Deelder and Magnus Palmblad

J Proteomics Bioinform 2012, 5:9