Milan completed his undergraduate master's degree in Chemistry (MChem) at the University of Warwick (2007-2011), where he worked on a final year project involving radical cyclisations of N-alkenyl-N-2-bromobenzyl acetamides under the supervision of Dr. Andrew Clark. He then moved to Canada in 2012 to complete a two-year MSc in Chemistry at Western with a specialization in molecular imaging under the supervision of Dr. Leonard G. Luyt. During that time, he synthesised a peptidomimetic radiotracer specifically targeting the ghrelin receptor for the purpose of PET imaging of prostate cancer.
Having developed a strong interest in molecular imaging, he began working as a research assistant on a collaborative project between the Kennedy Institute (Dr. Ngee Han Lim) and TDI (Professor Paul E. Brennan) at the University of Oxford in 2015. This involved synthesising a series of radiopaque peptides for the imaging of cartilage breakdown in osteoarthritis. He began his DPhil in October 2016, and his current research focuses on designing selective ADAMTS-4,-5 substrates to detect and image their proteinase activity in vivo. He is supervised by Dr. Ngee Han Lim (Kennedy) as well as Professor Tonia L. Vincent (Kennedy) and Professor Paul E. Brennan (TDI).
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity
Fowkes MM. et al, (2023), Journal of Medicinal Chemistry
Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents.
Fowkes MM. et al, (2022), PloS one, 17
Single Amino Acid Replacement in G-7039 Leads to a 70-fold Increase in Binding toward GHS-R1a.
Lalonde T. et al, (2019), ChemMedChem