Kilian Huber
Contact information
ChemBioHub - Huber Lab Website
https://orcid.org/0000-0002-1103-5300
NDM Research Building
Websites
- Huber Lab TDI Website
- Huber Lab SGC Website
- Podcast: Targeting Drug Discovery
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WIRED Feature
Learn more about our approach to open access drug discovery and scientific crowdsourcing
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Discovering Druggable Targets
Interview with Technology Networks
Kilian Huber
Principal Investigator
Chemical Biology - Drug Discovery - Proteomics - Systems Pharmacology - Medicinal Chemistry
Probing Biology with Small Molecules for Drug Target Discovery
The development of new medicines to treat diseases like cancer or inflammatory disorders is dependent on the identification of novel drug targets. Target selection requires an understanding of the functional relevance of a given protein in both physiological and pathophysiological conditions.
Chemical Biology combines chemistry and biology to generate small molecule tools, so-called “chemical probes”, that enable the functional exploration of cellular proteins with regard to their relevance for drug discovery. Candidate targets may originate from genetic studies linking the expression or mutation of a selected gene to a particular disease, in vitro genetic screens such as RNA-interference or genome-editing (e.g. CRISPR), compounds identified in phenotypic assays or drugs already in use.
To identify, explore and validate targets the Huber laboratory uses a variety of different discovery approaches such as small molecule screens, biochemical assays, protein X-ray crystallography, chemical and protein-protein interaction proteomics, medicinal chemistry, RNAi, genome-editing alongside classical molecular and cellular biology techniques aiming at the development of chemical probes that may provide leads for drug discovery.
Recent publications
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Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Journal article
Pinto-Fernandez A. et al, (2020), British journal of cancer
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Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Journal article
Kidd SL. et al, (2020), Chemical Science, 11, 10792 - 10801
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Deliberately Losing Control of C-H Activation Processes in the Design of Small Molecule Fragment Arrays Targeting Peroxisomal Metabolism.
Journal article
Kahn Tareque R. et al, (2020), ChemMedChem
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Quantifying CDK inhibitor selectivity in live cells.
Journal article
Wells CI. et al, (2020), Nature communications, 11
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Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
Journal article
Pinto-Fernandez A. et al, (2020)