Nicola Ternette
Dr, PhD
T-cell mediated immunity is reliant on the nature of the HLA-associated peptide pool presented on an infected cell or in tumour tissue. The specificity of this presentation determines the quality of the immunological response that can be elicited by cellular immune responses. My research focuses on qualitative and quantitative characterization of these cellular immunopeptidomes in the context of pathogen infection and cancer using mass spectrometry.
Recent publications
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In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies
Journal article
Pandey K. et al, (2020), Molecular Immunology, 123, 7 - 17
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The Choice of HLA-Associated Peptide Enrichment and Purification Strategy Affects Peptide Yields and Creates a Bias in Detected Sequence Repertoire.
Journal article
Nicastri A. et al, (2020), Proteomics
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Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).
Journal article
Chen L. et al, (2020), Molecular & cellular proteomics : MCP, 19, 871 - 883
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Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab.
Journal article
Powell Doherty RD. et al, (2020), Gastroenterology
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Identification of antigens presented by MHC for vaccines against tuberculosis.
Journal article
Bettencourt P. et al, (2020), NPJ Vaccines, 5