Iolanda Vendrell

Technologly Lead, Discovery Proteomics SRF

PhD

Iolanda Vendrell joined the Discovery Proteomics Facility at the University of Oxford in 2015, as a senior scientist in Biological Mass Spectrometry. She currently is the Technology Lead. She studied Biochemistry at the University of Barcelona and holds a PhD in Biochemistry (in the Neuroscience program) by the same University. Her interest in Proteomics and Mass Spectrometry started during her PhD. In 2007, she moved to the UK where she has been working in Proteomics labs in both Academia and Biotech companies. Over the years, Iolanda has developed an extensive expertise in using bottom up-proteomics for general discovery projects, biomarker discovery for clinical samples and post-translational modifications. Currently, one of her interest focuses on developing and implementing high-throughput proteomics platforms for clinical and non-clinical projects.

Recent publications

Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol

Llewellyn J. et al, (2026)

Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia

Liang Z. et al, (2024), Cell Reports, 43, 114152 - 114152

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

Tsukada K. et al, (2024), Molecular Cell, 84, 640 - 658.e10

Data‐independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis

Dellar ER. et al, (2024), Journal of Neurochemistry, 168, 115 - 127

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Chen Z. et al, (2022), Cell Death & Differentiation, 29, 1955 - 1969

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Technology Lead, Discovery Proteomics SRF

Contact information

Research groups

Iolanda Vendrell

Recent publications

Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol

Menin maintains enhancer-promoter interactions in a leukemia-specific manner

A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking

Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation

ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders

Protocol to profile spatially resolved NLRP3 inflammasome complexes using APEX2-based proximity labeling

Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

Data‐independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Age modulates protein-outcome associations in deceased donor kidneys

USP18 is an essential regulator of muscle cell differentiation and maturation

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.