Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Introduction

The Target Discovery Institute High Throughput Screening Facility is a resource open to research scientist interested in running high throughput screens using small compound and siRNA libraries. The TDI welcomes Screening Applications from academic investigators as well as industrial collaborators.  We are available for consultation and guidance both before and during the application process to ensure an efficient application process with minimal effort.

Our main goal at the TDI screening facility is to provide affordable access to research scientist interested in running high throughput screens as well as a resource with expertise in all aspects of high throughput screening. A fee is charged for access to small molecule and RNAi screening to help defray some of our operating cost (see below). A complete itemized summary of all costing will be made available to you after the screening application has been accepted. 

We encourage you to submit a TDI Letter of Interest / Screening Application as early as possible.

tdi-apply.gif

General TDI Fee Schedule for 2011

At present we have not fixed the TDI General Fee Schedule during this initial phase of the development of the TDI HTS Facility. In the interim, we intend to implement a system of only marginal cost recovery. All high throughput screens accepted during this initial phase will benefit from the marginal cost recovery scheme. Please contact Daniel Ebner for more information.

siRNA

  Fees for TDI Academic Partners and Oxford Research Scientists Fees for External Oxford
Initial consultation/guidance Free Free
Screen set-up fee (Optimization) Cost of consumables only Cost of consumables only plus development fee
Druggable genome in replicates of 2 Dependant on complexity and readout of screen.  Please contact Daniel Ebner for more information. To be determined
Genome wide in replicates of 2 Dependant on complexity and readout of screen.  Please contact Daniel Ebner for more information. To be determined

Small Compound Screening

  Fees for TDI Academic Partners and Oxford Research Scientists Fees for External Oxford
Initial consultation/guidance Free Free
Screen set-up fee (Optimization) Cost of consumables only Cost of consumables only plus development fee
1500 - 5000 compounds To be determined To be determined
Additional fee for projects screening 5001-10000 compounds To be determined To be determined
Greater than 10000 compounds To be determined To be determined

Once Screens are Accepted

Once the fees are agreed to, a data access and data sharing policy agreement will be signed and a written TDI Development and Production Schedule of your screen will be made. This schedule will detail the responsibilities of the screen developers (you) and the TDI high throughput staff as well as outline a time scale for the achievement of milestones for each step of the screen. All high throughput screens at the TDI are viewed as collaborations between the TDI and the development research scientists. In most cases, research scientists are strongly encouraged to participate in not only the transfer and optimization of the screen, but its production as well. We will work closely together during all stages of the screen to ensure successful project.

Additionally, the TDI is very interested in developing new screening technologies and processes and we welcome research scientist to discuss these ideas with us as collaborative ventures. In these cases, special arrangements to the fee schedule can be made to encourage these collaborations.  Please do not hesitate to contact Daniel Ebner with any questions you may have regarding the screening application process, fees, scheduling, or novel ideas you may have.

The TDI High Throughput Screening Facility is willing to assist you in providing information for grant applications as well as submitting Letters of Collaboration (Letter of Collaboration request would have to meet additional requirements, see below) for research scientist applying for grants intended to fund a screen. However, in both cases, please advise us of your intentions well in advance of grant application deadlines.