Associate Professor and Head of Discovery Proteomics Facility
In the Discovery Proteomics Facility of the Target Discovery Institute we provide advice in experimental design, sample preparation, sample analysis with state-of-the-art LCMS workflows and data analysis to researchers from Oxford University and national and international collaborators. We routinely use label-free quantitation, SILAC, TMT, SWATH and other methodologies on diverse samples (i.e. cells, tissues, immuno precipitates et al.) and have developed sample preparation techniques to access the deep proteome form little sample amounts using instrumentation such as Orbitrap Fusion Lumos or TimsTOF Pro.
My own interests evolve around clinical proteomics and applications for the spatial characterisation of the proteome in biological structures such as tissues and tumours. In addition, I am developing methodologies for the proteome characterisation of clinical cohort samples at high-throughput.
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
Tsukada K. et al, (2024), Molecular Cell
CD4 T cell contact drives macrophage cell cycle progression and susceptibility to lentiviral transduction
Mlcochova P. et al, (2024)
Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis.
Dellar ER. et al, (2023), J Neurochem
A hybrid electrospun-extruded polydioxanone suture for tendon tissue regeneration.
Abhari R. et al, (2023), Tissue engineering. Part A
Deep topographic proteomics of a human brain tumour.
Davis S. et al, (2023), Nat Commun, 14