Roman Fischer
Associate Professor and Head of Discovery Proteomics Facility
In the Discovery Proteomics Facility of the Target Discovery Institute we provide advice in experimental design, sample preparation, sample analysis with state-of-the-art LCMS workflows and data analysis to researchers from Oxford University and national and international collaborators. We routinely use label-free quantitation, SILAC, TMT, SWATH and other methodologies on diverse samples (i.e. cells, tissues, immuno precipitates et al.) and have developed sample preparation techniques to access the deep proteome form little sample amounts using instrumentation such as Orbitrap Fusion Lumos or TimsTOF Pro.
My own interests evolve around clinical proteomics and applications for the spatial characterisation of the proteome in biological structures such as tissues and tumours. In addition, I am developing methodologies for the proteome characterisation of clinical cohort samples at high-throughput.
Recent publications
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Lysosomal signalling pathways influence heart rhythm, and
regulate atrial function
Preprint
Burton REBECCA. et al, (2024)
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Association of Indoleamine 2,3-Dioxygenase (IDO) Activity with Outcome after Cardiac Surgery in Adult Patients
Journal article
Stieger A. et al, (2024), Metabolites, 14, 334 - 334
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Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
Preprint
Capel RA. et al, (2024)
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High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response
Journal article
Mi Y. et al, (2024), Science Translational Medicine, 16
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Identification of cellular retinoic acid binding protein 2 (CRABP2) as downstream target of nuclear factor I/X (NFIX): implications for skeletal dysplasia syndromes
Journal article
Kooblall KG. et al, (2024), JBMR Plus, 8