Roman Fischer
Associate Professor and Head of Discovery Proteomics Facility
In the Discovery Proteomics Facility of the Target Discovery Institute we provide advice in experimental design, sample preparation, sample analysis with state-of-the-art LCMS workflows and data analysis to researchers from Oxford University and national and international collaborators. We routinely use label-free quantitation, SILAC, TMT, SWATH and other methodologies on diverse samples (i.e. cells, tissues, immuno precipitates et al.) and have developed sample preparation techniques to access the deep proteome form little sample amounts using instrumentation such as Orbitrap Fusion Lumos or TimsTOF Pro.
My own interests evolve around clinical proteomics and applications for the spatial characterisation of the proteome in biological structures such as tissues and tumours. In addition, I am developing methodologies for the proteome characterisation of clinical cohort samples at high-throughput.
Recent publications
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The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
Journal article
Shorrocks A-MK. et al, (2021), Nature Communications, 12
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Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid.
Journal article
Wainwright SM. et al, (2021), Proceedings of the National Academy of Sciences of the United States of America, 118
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Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
Journal article
Feneberg E. et al, (2021), Brain Pathology
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Assessment of different screening methods for selecting palaeontological bone samples for peptide sequencing.
Journal article
Presslee S. et al, (2021), Journal of proteomics, 230
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Functional Genomic Analysis of a RUNX3 Polymorphism Associated with Ankylosing Spondylitis.
Journal article
Vecellio M. et al, (2020), Arthritis & rheumatology (Hoboken, N.J.)